-, Baig M.S., Kolasa-Wolosiuk A., Pilutin A., Safranow K., Baranowska-Bosiacka I., Kabat-Koperska J., Wiszniewska B. Finasteride-induced inhibition of 5alpha-reductase type 2 could lead to kidney damage-animal, experimental study. Biomolecules. AR: androgen receptor; DHP: dihydroprogesterone; DHT: dihydrotestosterone; ER: estrogen receptor beta; PR: progesterone receptor; PROG: progesterone; T: testosterone; THP: tetrahydroprogesterone. What the hell? How much worse can it get then being a lifeless piece of flesh that hasnt been erect or had any kind of sensation in months and months? Not orgasm strength and sperm levels have returned, just waiting on my brain to communicate with my penis when its time for sexual intercourse. That is 250IU, not a typo so youll mix your 5000iu HCG with 5CC water and take 1/4 CC intramuscular three times a week using an insulin needle Have you heard about it? I only said everyone should read it, especially in light of the big new proviron recovery on the forum there. After stopping 7 weeks later (when I ran out of my proviron), things felt off for a few weeks but then after around two months I got back to my pre-PFS state. Perhaps if I had tried it longer it would have helped more, Im not sure. So yes, it is not Dermatologic Surgeon, Board Certified in Dermatology, How Long Does Minoxidil 5 Take to Work? Therefore, understand that I can't promise this will work for youbut for me? Ive read theres on guy there who recoverd recently from HCG, very interesting. Get the latest in health news delivered to your inbox! (photo). Therefore, I cut the pills in half (2.5mg) and toss the other half. I need to get back over there and check it out I guess. At some point you just cant store it all or want to use old drug. Maybe if theyre lucky in 10 years. Please enable it to take advantage of the complete set of features! However, careful selection of patients and monitoring the finasteride treatment may prevent the PFS to some extent. At higher doses, finasteride (Proscar) can also treat benign prostatic hyperplasia (BPH). After taking 50mg of Proviron I got my first erection in years. J. Clin. Finasteride causes cognitive & sexual decline. I took a prescription-strength anti-estrogen, Tamoxifen 10mg, twice a day: one at around 3pm and another one together with my test booster before bedtime. Since it only comes in 5 and 1 mg pills, there isnt much of a choice. And quite frankly, if you think big pharma doesn't have millions and millions of dollars wrapped up in trying to cover up just how severely finasteride has destroyed mens' lives, you're fooling yourself. -. The number of men sharing their experience of Post-Finasteride Syndrome is steadily rising, painting a bleak picture of the life-shattering effects the drug can have. Clinical features reported in patients affected by post-finasteride syndrome. Do you have cloudy urine after an orgasm? I could be wrong but none of them seem to have anhedonia or genital numbness or fatigue or insomnia or anything, just libido and ED issues. As a 5-alpha reductase inhibitor, finasteride works by inhibiting the effects of the enzyme thats responsible for converting testosterone into dihydrotestosterone (DHT). Am I at risk of complications from this condition? Melcangi RC, Caruso D, Abbiati F, Giatti S, Calabrese D, Piazza F, Cavaletti G. J Sex Med. Best, Dr. Emer. A single copy of these materials may be reprinted for noncommercial personal use only. Your doctor will want to determine whether your dry orgasms are retrograde ejaculation or linked to another problem that may need further evaluation. Drugs to treat retrograde ejaculation are drugs primarily used to treat other conditions, including: These medications help keep the bladder neck muscle closed during ejaculation. Finasteride is available as a lower-cost generic. 12th ed. The supplement is making real changes in my body and mind, and it feels incredible. I read the thing on Healthline where it says it doesn't raise testosterone in humans. PMC I was on TRT when I got PFS. WebPost-finasteride syndrome occurs in men whove taken finasteride to treat hair loss or enlarged prostates. 2019;16 doi: 10.3390/ijerph16101726. I guess that never happened. Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5-Reductase Inhibitory, Anti-Inflammatory, and In Vivo Anti-Hair Loss Effects. However, the side effects of a medication usually go away when you stop taking it. ._1LHxa-yaHJwrPK8kuyv_Y4{width:100%}._1LHxa-yaHJwrPK8kuyv_Y4:hover ._31L3r0EWsU0weoMZvEJcUA{display:none}._1LHxa-yaHJwrPK8kuyv_Y4 ._31L3r0EWsU0weoMZvEJcUA,._1LHxa-yaHJwrPK8kuyv_Y4:hover ._11Zy7Yp4S1ZArNqhUQ0jZW{display:block}._1LHxa-yaHJwrPK8kuyv_Y4 ._11Zy7Yp4S1ZArNqhUQ0jZW{display:none} I has numbness also. 2015 Sep;16(3):177-98. doi: 10.1007/s11154-015-9319-y. Your doctor might also ask about any health problems, surgeries or cancers you've had and what medications you take. Please note the date of last review or update on all articles. I suspect its because my E2 was so low already and that made it feel even lower (single digits if I recall correctly). They kept saying it was on the verge of having a major announcement 2 YEARS ago. If your doctor suspects your dry orgasm is something other than retrograde ejaculation, you might need further tests or a referral to a specialist to find the cause. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. https://camas.github.io/reddit-search/#{%22author%22:%22mrgoodcat1990%22,%22resultSize%22:100,%22query%22:%22pssd%20numbness%22}, ._3K2ydhts9_ES4s9UpcXqBi{display:block;padding:0 16px;width:100%} In addition, it has been also reported that persistent side effects may occur in some AGA patients. Next steps is likely getting a Hey there, To be honest, I think for the most part these recoveries werent PFS but rather hormonal imbalances. A. Finasteride (sold as Proscar and generic brands) is prescribed for symptoms of an enlarged prostate; it's also used at a lower strength (under the name Propecia) for male pattern baldness. WebPost-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or Shift work can harm sleep and health: What helps? Is Post Finasteride Syndrome Real? Its like they want to hide possible solutions. I am not aware of the use of Human Growth Hormone in the treatment for Post Finasteride Syndrome. Are there other possible causes for my symptoms or condition? J Sex Med. Its less than ideal though when trying to help people and you get banned for it, That forum is a farce, it seems their solution is to just wait, could help for some but others are waiting for years without improving. Ive seen this several times over there. The article stated proviron was the best potential cure in his opinion. I read about the Post-Fin Syndrome and decided to quit (Almost) No erections, no libido. The presence of side effects during pharmacological treatment is unfortunately a quite common problem. I'll be interested to see if this has any effects on my weight loss endeavors. Yeah the joe_kool guy or whatever his name is had really good luck with TRT, he is honestly the reason I went down this road. Over time, several studies have demonstrated that finasteride is a safe and well-tolerated drug, with rare and reversible side effects such as reduced sexual libido and ejaculatory volume, most commonly observed when prescribed in Their attitude is 100% there is no cure, it wont get better, nothing works, anything that does work doesnt work long term, and thats just how it is. I think it took 6 months before i felt ready to meet a girl again. Stopping finasteride treatment can cause post-finasteride syndrome. ._1aTW4bdYQHgSZJe7BF2-XV{display:-ms-grid;display:grid;-ms-grid-columns:auto auto 42px;grid-template-columns:auto auto 42px;column-gap:12px}._3b9utyKN3e_kzVZ5ngPqAu,._21RLQh5PvUhC6vOKoFeHUP{font-size:16px;font-weight:500;line-height:20px}._21RLQh5PvUhC6vOKoFeHUP:before{content:"";margin-right:4px;color:#46d160}._22W-auD0n8kTKDVe0vWuyK,._244EzVTQLL3kMNnB03VmxK{display:inline-block;word-break:break-word}._22W-auD0n8kTKDVe0vWuyK{font-weight:500}._22W-auD0n8kTKDVe0vWuyK,._244EzVTQLL3kMNnB03VmxK{font-size:12px;line-height:16px}._244EzVTQLL3kMNnB03VmxK{font-weight:400;color:var(--newCommunityTheme-metaText)}._2xkErp6B3LSS13jtzdNJzO{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;margin-top:13px;margin-bottom:2px}._2xkErp6B3LSS13jtzdNJzO ._22W-auD0n8kTKDVe0vWuyK{font-size:12px;font-weight:400;line-height:16px;margin-right:4px;margin-left:4px;color:var(--newCommunityTheme-actionIcon)}._2xkErp6B3LSS13jtzdNJzO .je4sRPuSI6UPjZt_xGz8y{border-radius:4px;box-sizing:border-box;height:21px;width:21px}._2xkErp6B3LSS13jtzdNJzO .je4sRPuSI6UPjZt_xGz8y:nth-child(2),._2xkErp6B3LSS13jtzdNJzO .je4sRPuSI6UPjZt_xGz8y:nth-child(3){margin-left:-9px} ._1QwShihKKlyRXyQSlqYaWW{height:16px;width:16px;vertical-align:bottom}._2X6EB3ZhEeXCh1eIVA64XM{margin-left:3px}._1jNPl3YUk6zbpLWdjaJT1r{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;display:inline-block;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;padding:0 4px}._1jNPl3YUk6zbpLWdjaJT1r._39BEcWjOlYi1QGcJil6-yl{padding:0}._2hSecp_zkPm_s5ddV2htoj{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;display:inline-block;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;margin-left:0;padding:0 4px}._2hSecp_zkPm_s5ddV2htoj._39BEcWjOlYi1QGcJil6-yl{padding:0}._1wzhGvvafQFOWAyA157okr{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;box-sizing:border-box;line-height:14px;padding:0 4px}._3BPVpMSn5b1vb1yTQuqCRH,._1wzhGvvafQFOWAyA157okr{display:inline-block;height:16px}._3BPVpMSn5b1vb1yTQuqCRH{background-color:var(--newRedditTheme-body);border-radius:50%;margin-left:5px;text-align:center;width:16px}._2cvySYWkqJfynvXFOpNc5L{height:10px;width:10px}.aJrgrewN9C8x1Fusdx4hh{padding:2px 8px}._1wj6zoMi6hRP5YhJ8nXWXE{font-size:14px;padding:7px 12px}._2VqfzH0dZ9dIl3XWNxs42y{border-radius:20px}._2VqfzH0dZ9dIl3XWNxs42y:hover{opacity:.85}._2VqfzH0dZ9dIl3XWNxs42y:active{transform:scale(.95)} Elsevier; 2022. https://www.clinicalkey.com. doi: 10.1007/s00213-014-3567-5. I have the desire for sex and intimacy but my brain simply wont communicate with my penis when its time for intercourse. Waitttt wait wait. Retrograde ejaculation typically doesn't require treatment unless it interferes with fertility. I do not think we have an answer to that question one way or the other. Incredible! This site complies with the HONcode standard for trustworthy health information: verify here. I remember being depressed, emasculated, and hopeless. I'll never be without this stuff again. Is there a generic alternative to the medicine you're prescribing me? eCollection 2021 Oct. See this image and copyright information in PMC. ._2FKpII1jz0h6xCAw1kQAvS{background-color:#fff;box-shadow:0 0 0 1px rgba(0,0,0,.1),0 2px 3px 0 rgba(0,0,0,.2);transition:left .15s linear;border-radius:57%;width:57%}._2FKpII1jz0h6xCAw1kQAvS:after{content:"";padding-top:100%;display:block}._2e2g485kpErHhJQUiyvvC2{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;-ms-flex-pack:start;justify-content:flex-start;background-color:var(--newCommunityTheme-navIconFaded10);border:2px solid transparent;border-radius:100px;cursor:pointer;position:relative;width:35px;transition:border-color .15s linear,background-color .15s linear}._2e2g485kpErHhJQUiyvvC2._3kUvbpMbR21zJBboDdBH7D{background-color:var(--newRedditTheme-navIconFaded10)}._2e2g485kpErHhJQUiyvvC2._3kUvbpMbR21zJBboDdBH7D._1L5kUnhRYhUJ4TkMbOTKkI{background-color:var(--newRedditTheme-active)}._2e2g485kpErHhJQUiyvvC2._3kUvbpMbR21zJBboDdBH7D._1L5kUnhRYhUJ4TkMbOTKkI._3clF3xRMqSWmoBQpXv8U5z{background-color:var(--newRedditTheme-buttonAlpha10)}._2e2g485kpErHhJQUiyvvC2._1asGWL2_XadHoBuUlNArOq{border-width:2.25px;height:24px;width:37.5px}._2e2g485kpErHhJQUiyvvC2._1asGWL2_XadHoBuUlNArOq ._2FKpII1jz0h6xCAw1kQAvS{height:19.5px;width:19.5px}._2e2g485kpErHhJQUiyvvC2._1hku5xiXsbqzLmszstPyR3{border-width:3px;height:32px;width:50px}._2e2g485kpErHhJQUiyvvC2._1hku5xiXsbqzLmszstPyR3 ._2FKpII1jz0h6xCAw1kQAvS{height:26px;width:26px}._2e2g485kpErHhJQUiyvvC2._10hZCcuqkss2sf5UbBMCSD{border-width:3.75px;height:40px;width:62.5px}._2e2g485kpErHhJQUiyvvC2._10hZCcuqkss2sf5UbBMCSD ._2FKpII1jz0h6xCAw1kQAvS{height:32.5px;width:32.5px}._2e2g485kpErHhJQUiyvvC2._1fCdbQCDv6tiX242k80-LO{border-width:4.5px;height:48px;width:75px}._2e2g485kpErHhJQUiyvvC2._1fCdbQCDv6tiX242k80-LO ._2FKpII1jz0h6xCAw1kQAvS{height:39px;width:39px}._2e2g485kpErHhJQUiyvvC2._2Jp5Pv4tgpAsTcnUzTsXgO{border-width:5.25px;height:56px;width:87.5px}._2e2g485kpErHhJQUiyvvC2._2Jp5Pv4tgpAsTcnUzTsXgO ._2FKpII1jz0h6xCAw1kQAvS{height:45.5px;width:45.5px}._2e2g485kpErHhJQUiyvvC2._1L5kUnhRYhUJ4TkMbOTKkI{-ms-flex-pack:end;justify-content:flex-end;background-color:var(--newCommunityTheme-active)}._2e2g485kpErHhJQUiyvvC2._3clF3xRMqSWmoBQpXv8U5z{cursor:default}._2e2g485kpErHhJQUiyvvC2._3clF3xRMqSWmoBQpXv8U5z ._2FKpII1jz0h6xCAw1kQAvS{box-shadow:none}._2e2g485kpErHhJQUiyvvC2._1L5kUnhRYhUJ4TkMbOTKkI._3clF3xRMqSWmoBQpXv8U5z{background-color:var(--newCommunityTheme-buttonAlpha10)} Around 8 months and i was pretty much recovered. While they're often an effective treatment for retrograde ejaculation, medications can cause side effects or adverse reactions with other medications. The .gov means its official. Adverse effects of common medications on male fertility. 2022 Oct;11(10):1452-1457. doi: 10.21037/tau-22-92. -, Alkahtane A.A., Albasher G., Al-Sultan N.K., Alqahtani W.S., Alarifi S., Almeer R.S., Alghamdi J., Ali D., Alahmari A., Alkahtani S. Long-term treatment with finasteride induces apoptosis and pathological changes in female mice. Of course I said this in a respectable manner Result: post deleted and banned. The data does support that finasteride does have sexual side-effects for guys that are not on TRT while you are using it. 2023 by The President and Fellows of Harvard College, Do not sell my personal information | Privacy Policy. WTF. What's the best treatment to use to try to get my partner pregnant? Im suffering from pfs for 3+ years now so pfs is very real sadly but I believe the dudes article is the best explenation Ive read so far. That's one of the mildest forms of PFS you can experience. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). ._3Qx5bBCG_O8wVZee9J-KyJ{border-top:1px solid var(--newCommunityTheme-widgetColors-lineColor);margin-top:16px;padding-top:16px}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN{margin:0;padding:0}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ{font-family:Noto Sans,Arial,sans-serif;font-size:14px;font-weight:400;line-height:21px;display:-ms-flexbox;display:flex;-ms-flex-pack:justify;justify-content:space-between;-ms-flex-align:center;align-items:center;margin:8px 0}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ.QgBK4ECuqpeR2umRjYcP2{opacity:.4}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ label{font-size:12px;font-weight:500;line-height:16px;display:-ms-flexbox;display:flex;-ms-flex-align:center;align-items:center}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ label svg{fill:currentColor;height:20px;margin-right:4px;width:20px;-ms-flex:0 0 auto;flex:0 0 auto}._3Qx5bBCG_O8wVZee9J-KyJ ._4OtOUaGIjjp2cNJMUxme_{-ms-flex-pack:justify;justify-content:space-between}._3Qx5bBCG_O8wVZee9J-KyJ ._4OtOUaGIjjp2cNJMUxme_ svg{display:inline-block;height:12px;width:12px}._2b2iJtPCDQ6eKanYDf3Jho{-ms-flex:0 0 auto;flex:0 0 auto}._4OtOUaGIjjp2cNJMUxme_{padding:0 12px}._1ra1vBLrjtHjhYDZ_gOy8F{font-family:Noto Sans,Arial,sans-serif;font-size:12px;letter-spacing:unset;line-height:16px;text-transform:unset;--textColor:var(--newCommunityTheme-widgetColors-sidebarWidgetTextColor);--textColorHover:var(--newCommunityTheme-widgetColors-sidebarWidgetTextColorShaded80);font-size:10px;font-weight:700;letter-spacing:.5px;line-height:12px;text-transform:uppercase;color:var(--textColor);fill:var(--textColor);opacity:1}._1ra1vBLrjtHjhYDZ_gOy8F._2UlgIO1LIFVpT30ItAtPfb{--textColor:var(--newRedditTheme-widgetColors-sidebarWidgetTextColor);--textColorHover:var(--newRedditTheme-widgetColors-sidebarWidgetTextColorShaded80)}._1ra1vBLrjtHjhYDZ_gOy8F:active,._1ra1vBLrjtHjhYDZ_gOy8F:hover{color:var(--textColorHover);fill:var(--textColorHover)}._1ra1vBLrjtHjhYDZ_gOy8F:disabled,._1ra1vBLrjtHjhYDZ_gOy8F[data-disabled],._1ra1vBLrjtHjhYDZ_gOy8F[disabled]{opacity:.5;cursor:not-allowed}._3a4fkgD25f5G-b0Y8wVIBe{margin-right:8px} After a few days I starting liking women again and became sexually from frustrated. WebPost finasteride syndrome is real. Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats. Pharmaceuticals (Basel). HHS Vulnerability Disclosure, Help Check his posts and look at the reasons. Fertility and Sterility. What medications or herbal remedies do you take? Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology. Examine your urine for the presence of semen after you have an orgasm. I have not made any drastic life changes since beginning this. The symptoms of PFS start to subside within four to eight months after discontinuing the medicine. Answer: Hormonal optimization while on finesteride there are many options including peptides, and HCG as well as clomid/arimidex. Drugs generally won't help if retrograde ejaculation is due to surgery that causes permanent physical changes of your anatomy. If your doctor thinks drugs you are taking might be affecting your ability to ejaculate normally, he or she might have you stop taking them for a period of time. reading time: 43 2018;120:143149. Male pattern baldness develops when DHT binds to receptors in the scalp and causes the hair follicles to miniaturize. Toxicol. Teeranachaideekul V, Parichatikanond W, Junyaprasert VB, Morakul B. To give you a bit of background, I'm a 34 year old male whose sexual function was utterly destroyed by finasteride/Propecia. 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